Diclogen gel instructions for use. Diclogen ointment from what helps. Use in elderly patients

Diclogen ointment is a drug that has anti-inflammatory and analgesic effects. This remedy, when applied topically, provides an active therapeutic and anti-symptomatic effect, helping to get rid of the discomfort and inflammatory processes that occur with certain diseases. The use of the ointment is indicated for various diseases of the musculoskeletal system and other pathological conditions. Use Diclogen strictly according to the instructions.

Interesting! Like many other drugs, Diclogen is available in several dosage forms. In addition to the local preparation in the form of an ointment, oral tablets are also produced, including a prolonged form of tablets, as well as a solution for intravenous or intramuscular administration. Each of the forms of this drug has special nuances in use, specific indications and rules for use. Be sure to consult with your doctor, who will tell you which of the forms will be most effective in your case, and clarify the features of the application.

Indications

Dicogen ointment is a popular and inexpensive drug intended for topical use. This drug is used to provide anti-inflammatory and analgesic effects. The use of the ointment helps speed up the healing process and relieves unpleasant and uncomfortable symptoms.

Indications for the use of Diclogen ointment are such diseases:

  • Pain and swelling that occurs in the muscles and joints;
  • Inflammatory diseases that affect the tissues of the joint and soft tissues;
  • Various types of arthrosis;
  • Radiculitis;
  • Rheumatoid diseases of the joints;
  • Rheumatic lesions of the soft tissues of the joint;
  • Inflammatory processes of soft tissues and joints resulting from injuries and bruises.

In addition, the drug will be effective in a number of other inflammatory phenomena, when it is necessary to anesthetize the affected skin area and cope with unpleasant symptoms.

Please note that other dosage forms of Diclogen have slightly different indications for use. It is forbidden to use Diclogen ointment if there are such contraindications for use:

  • Allergic reaction to acetylsalicylic acid in history;
  • Individual intolerance to the substances contained in the composition, as well as other non-steroidal anti-inflammatory substances;
  • Damage and wounds on the skin in the area where the drug is planned to be applied;
  • Children who have not reached the age of 6 years;
  • Pregnancy and lactation.

Important! With the local use of the drug Diclogen possible side effects which are manifested by an allergic reaction, photosensitivity or contact dermatitis.

Composition

Ointment Diclogen is a local drug that helps to cope with various diseases of the musculoskeletal system. This remedy is prescribed by specialists for many diseases of the joints and soft tissues.

The therapeutic effect of Diclogen is due to the sodium diclofenac present in its composition. This active ingredient belongs to non-steroidal anti-inflammatory drugs, which are widely used in pharmacology for the treatment of various ailments.

Diclofenac gives the ointment special properties. It helps to get rid of the inflammatory process that occurs in the affected tissues. Its action is due to the fact that diclofenac inhibits the release of inflammatory mediators, causing the inflammatory process to fade.

In addition, this active ingredient has an analgesic effect, which is also very important for various diseases of the joints and soft tissues. It prevents the spread of a painful impulse through nerve receptors, gives a feeling of comfort and makes the patient feel better.

In addition to the active substance of diclofenac, the ointment contains a whole complex of auxiliary ingredients necessary to give the drug the necessary texture and consistency.

What is the price? The price of Diclogen ointment is approximately 70 rubles for a tube of 50 grams and 50 rubles for a product in a package of 30 grams.

Conclusion

Diclogen ointment is an active pharmacological agent for topical use, which has anti-inflammatory and analgesic properties. This drug helps to cope with inflammation and pain that occurs when soft tissues and joints are affected. The tool has an effective effect and actively fights with unpleasant sensations.

mazimed.ru

Diclogen - instructions for use, indications, doses, analogues

Diclogen is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects.

Release form and composition

  • Gel for external use 1% and 5%: almost white color, translucent, with a specific smell (30 and 50 g each in aluminum tubes, 1 tube in a cardboard box);
  • Enteric-coated tablets: round, biconvex, light brown in color, with beveled edges (10 pieces in blisters or blister packs, in a carton pack of 5 blisters or packs);
  • Prolonged-release tablets, enteric-coated: round, biconvex, pink, with bevelled edges (10 pcs. in blister packs, 2 packs in a carton box);
  • Solution for intramuscular and intravenous administration: transparent, from colorless to yellowish color (3 ml in ampoules: 5 ampoules in contour plastic packs, in a cardboard bundle 1 or 2 packs; 10 ampoules in contour plastic packs, in a cardboard bundle 1 pack ).

The active substance of Diclogen is diclofenac sodium:

  • 1 g of gel - 10 or 50 mg;
  • 1 enteric-coated tablet - 50 mg;
  • 1 tablet of prolonged action - 100 mg;
  • 1 ml solution for injection - 25 mg.

Excipients:

  • Gel: liquid paraffin, isopropanol, trolamine, disodium edetate, carbomer, chlorocresol, polysorbate 80, propylene glycol, benzyl alcohol, sodium sulfite, purified water, lavender oil;
  • Enteric coated tablets: corn starch, povidone, calcium dihydrogen phosphate, sodium starch glycolate, lactose, isopropyl alcohol, purified talc, methylene chloride, magnesium stearate, yellow dye (Opadry Yellow mix / OY-P-5290);
  • Long-acting enteric-coated tablets: hydroxypropyl methylcellulose, guar gum, povidone, isopropyl alcohol, magnesium stearate, purified talc, dextrose. Shell composition: hydroxypropyl methylcellulose, titanium dioxide, propylene glycol, isopropyl alcohol, purified talc, ethyl cellulose, methylene chloride, red iron oxide;
  • Solution for injection: sodium sulfite anhydrous, benzyl alcohol, mannitol, hydrochloric acid, propylene glycol, water for injection.

Indications for use

Gel for external use

  • Pain and swelling caused by diseases of the muscles and joints: radiculitis, osteoarthritis, sciatica, lumbago, rheumatoid arthritis and muscle pain, including rheumatic origin;
  • Rheumatic diseases of soft tissues: bursitis, tendovaginitis, damage to periarticular tissues;
  • Post-traumatic inflammation of soft tissues and joints (for example, due to bruises, overexertion and sprains).
  • Pain syndrome and swelling caused by diseases of the muscles and joints: myalgia, neuralgia, lumbago, sciatica;
  • Inflammatory diseases of the periarticular tissues: bursitis, tendovaginitis, rheumatic soft tissue lesions;
  • Degenerative diseases of the musculoskeletal system: osteochondrosis, deforming osteoarthritis;
  • Inflammatory diseases of the musculoskeletal system: ankylosing spondylitis, gout, arthritis (rheumatoid, juvenile, psoriatic, gouty);
  • Post-traumatic pain syndrome with inflammation, postoperative pain;
  • Renal/hepatic colic;
  • Migraine;
  • Adnexitis, proctitis, primary algomenorrhea;
  • Complex therapy of infectious and inflammatory diseases of the upper respiratory tract, accompanied by severe pain syndrome: otitis media, tonsillitis, pharyngitis.

Contraindications

For all dosage forms:

  • History of aspirin asthma (attack of bronchial obstruction, rhinitis and urticaria after taking acetylsalicylic acid or other NSAIDs);
  • Pregnancy and lactation;
  • Individual hypersensitivity to the components of the drug or other NSAIDs.

Additionally for the gel:

  • Violation of the integrity of the skin;
  • Children's age up to 6 years;
  • III trimester of pregnancy.

Additionally for tablets and solution for injection:

  • Erosive and ulcerative lesions gastrointestinal tract in the acute phase;
  • Hematopoietic disorders;
  • Children's age up to 6 years - for coated tablets, up to 18 years - for prolonged-release tablets and injection solution;
  • Pregnancy and lactation.

Diclogen should be used with caution in the following cases:

  • Gel: severe disorders of the liver and / or kidneys, exacerbation of hepatic porphyria, erosive and ulcerative lesions of the gastrointestinal tract, bronchial asthma, chronic heart failure, impaired blood clotting (including bleeding tendency, prolongation of bleeding time, hemophilia), I and II trimesters of pregnancy, advanced age;
  • Tablets: heart failure, severe impairment of liver and / or kidney function, induced acute hepatic porphyria, as well as in elderly patients and patients who, for any reason, have a decrease in the volume of circulating fluid (for example, after extensive surgery);
  • Solution for injection: heart failure, severe impairment of liver and / or kidney function.

Method of application and dosage

Gel for external use

In the form of a gel, Diclogen is applied externally, lightly rubbing, 2 times a day.

The required amount of the drug depends on the size of the painful area. The maximum allowable single doses: children over 12 years old and adults - 2 g, children 6-12 years old - 1 g.

The duration of treatment is determined individually depending on the indications and the effectiveness of the therapy. After 2 weeks of using the drug, you should consult a doctor.

Enteric coated tablets

Diclogen should be taken orally by swallowing the tablets whole with plenty of water. To quickly achieve a therapeutic effect, it is recommended to take the drug 30 minutes before a meal, in other cases - during or after a meal.

Adults are prescribed 1 tablet 2-3 times a day. After reaching the optimal therapeutic effect, gradually reduce the dose and transfer the patient to maintenance therapy at a daily dose of 50 mg (1 tablet).

Children over 12 years of age are prescribed no more than 2 mg / kg of body weight. In juvenile rheumatoid arthritis, the dose may be increased to 3 mg/kg.

Prolonged release tablets

Diclogen should be taken orally by swallowing the tablets whole with plenty of water. To quickly achieve a therapeutic effect, it is recommended to take the drug 30 minutes before meals, in other cases - regardless of meals.

Doses are selected individually depending on the type and severity of the course of the disease.

Adults are usually prescribed 1 tablet (100 mg) 1 time per day. The duration of treatment is determined by the doctor.

Solution for intramuscular and intravenous administration

Intravenously, the drug is administered by drip in a daily dose of not more than 150 mg. Immediately before administration, the contents of 1 ampoule of Diclogen are diluted with 100-500 ml of glucose solution 5% or sodium chloride solution 0.9%, having previously added a solution of 1 ml of 4.2% or 0.5 ml of 8.4% to sodium bicarbonate infusion solutions. The duration of the infusion, depending on the severity of the pain syndrome, can range from 30 to 180 minutes. Intravenously, the drug can be administered for no more than 2 days.

To prevent postoperative pain, Diclogen infusion is carried out in a “shock” dose - 25-50 mg for 15-60 minutes, then the introduction is continued at a rate of 5 mg / hour until the maximum allowable daily dose of 150 mg is reached.

To stop the pain syndrome caused by exacerbation of chronic diseases, and for the treatment of acute conditions, you can administer the drug intramuscularly 1-2 times, and then transfer the patient to the oral form of Diclogen (total daily dose should not exceed 150 mg). The solution is injected deep intramuscularly for no more than 2 days.

Side effects

When using Diclogen in the form of a gel:

  • Local reactions: photosensitivity, eczema, contact dermatitis (papules, swelling of the treated area of ​​the skin, vesicles, redness, peeling, itching);
  • Systemic reactions: photosensitivity, generalized skin rash, allergic reactions(urticaria, bronchospastic reactions, angioedema).

When using Diclogen in the form of tablets and solution for injection:

  • Digestive system: anorexia, flatulence, nausea, vomiting, gastralgia, abdominal pain, diarrhea, constipation, gastrointestinal bleeding (melena, hematemesis), increased activity of hepatic transaminases, dry mouth, glossitis, aphthous stomatitis, erosive and ulcerative lesions of the gastrointestinal intestinal tract, pancreatitis, hepatitis (including jaundice), nonspecific colitis with bleeding, fulminant hepatitis;
  • Nervous system: decreased memory, hearing and visual acuity, tinnitus, diplopia, impaired perception, dizziness, loss of orientation, headache, anxiety, insomnia, paresthesia, irritability, fatigue, psychotic reactions, tremor, taste disturbance, scotoma, nightmares, depression, convulsions, aseptic meningitis;
  • Organs of hematopoiesis: hemolytic and aplastic anemia, leukopenia, thrombocytopenia, agranulocytosis;
  • Cardiovascular system: chest pain, palpitations, increased blood pressure, arrhythmias;
  • Urinary system: papillary necrosis, nephrotic syndrome, oliguria, proteinuria, hematuria, cystitis, interstitial nephritis, acute renal failure;
  • Skin: photosensitivity, alopecia, skin rash (mainly urticarial and erythematous), pruritus, eczema, erythroderma, allergic purpura, angioedema, toxic epidermal necrolysis, erythema multiforme exudative;
  • Others: systemic anaphylactic reactions (including shock), edema, bronchospasm, impotence.

special instructions

Diclogen Gel should only be applied to undamaged skin, avoiding contact with open wounds. Do not apply an occlusive dressing. Wash hands thoroughly after application. Avoid contact with eyes and mucous membranes.

When prescribing the drug in the form of tablets and solution for injection to the elderly (especially those receiving diuretics), patients with renal or heart failure, as well as patients who have a decrease in the volume of circulating fluid, it is necessary to monitor kidney function. Patients with hepatic insufficiency during long-term therapy require monitoring of the picture of peripheral blood and liver function, conducting stool tests for occult blood.

When treating with Diclogen in the form of tablets or solution for injection, it is necessary to refrain from driving and potentially dangerous species activities that require a high reaction rate and increased attention.

drug interaction

Gel for external use

Diclogen may enhance the effect of drugs that cause photosensitivity.

There is no information on clinically significant interactions with other drugs.

Tablets and solution for injection

  • Lithium preparations, cyclosporine, digoxin: their plasma concentration increases;
  • Potassium-sparing diuretics: the risk of developing hyperkalemia increases;
  • Diuretics, hypnotics and antihypertensive drugs: their effectiveness decreases;
  • Anticoagulants, thrombolytic agents (streptokinase, alteplase, urokinase): the risk of bleeding increases;
  • Acetylsalicylic acid: the concentration of diclofenac in the blood decreases;
  • Methotrexate: its toxicity increases;
  • Other NSAIDs, glucocorticosteroids: increased likelihood of side effects, including gastrointestinal bleeding;
  • Oral antidiabetic drugs: increased risk of hyper- or hypoglycemia;
  • Cyclosporine: its nephrotoxicity increases;
  • Valproic acid, cefoperazone, plicamycin, cefamandol, cefotetan: the incidence of hypoprothrombinemia increases;
  • Gold preparations, cyclosporine, paracetamol: Diclogen nephrotoxicity increases;
  • Glucocorticosteroids, corticotropin, St. John's wort, colchicine, alcohol: the risk of developing gastrointestinal complications accompanied by bleeding increases;
  • Vasodilators: their hypotensive activity decreases.

Analogues

Analogues of Diclogen are: Diclofenac, Diclofenac-Akos, Diclofenac Retard, Diklak, Diclovit, Voltaren, Voltaren Emulgel, Ortofen.

Terms and conditions of storage

Store in a place protected from light, dry and out of the reach of children at temperatures up to 25 ºС. Do not freeze.

Shelf life - 3 years.

Terms of dispensing from pharmacies

Tablets and solution are dispensed by prescription, the gel is dispensed without a prescription.

www.neboleem.net

Diclogen

Diclogen is a non-steroidal anti-inflammatory drug (NSAID).

Release form and composition

For external use, the drug is available in the form of a gel and Diclogen ointment: gel - in aluminum tubes of 30 and 50 g, ointment - 30 g each. The active substance is diclofenac sodium, contained in an amount of 10 mg per 1 g of the drug. The auxiliary substances that make up the Diclogen gel are: propylene glycol, disodium edetate, liquid paraffin, sodium sulfite, chlorocresol, polysorbate, ethanol, lavender oil, purified water.

Pharmacological action of Diclogen

Diclogen is a drug belonging to the group of NSAIDs and has analgesic, anti-exudative and anti-inflammatory properties. Being a derivative of phenylacetic acid, the drug interferes with the metabolism of arachidonic acid, inhibits the synthesis of prostaglandins, which cause inflammation and pain. When applied topically, Diclogen helps to reduce inflammation in the joints and relieve pain, reduces morning stiffness of the joints, normalizes their functions, relieves swelling. Possessing a water-alcohol base, Diclogen gel has a mild local anesthetic effect.

Indications for use

As indicated in the instructions for Diclogen, the drug is prescribed for

  • Osteoarthritis of peripheral joints and spine;
  • Rheumatic lesions of soft tissues;
  • ankylosing spondylitis;
  • Chronic and juvenile rheumatoid arthritis;
  • Psoriatic and gouty arthritis;
  • Post-traumatic inflammation of soft tissues, joints and ligaments;
  • Muscular pain of non-rheumatic origin.

Also, according to reviews, Diclogen is successfully used to eliminate pain.

Contraindications

The drug in the form of a gel and ointment Diclogen according to the instructions is contraindicated for use with:

  • Children under 6 years of age;
  • The period of breastfeeding;
  • Pregnancy in the 3rd trimester;
  • Hypersensitivity to diclofenac or other components of the drug;
  • Damage to the integrity of the skin at the site of application.

It is not recommended to use the drug if the patient's history contains data on attacks of bronchial obstruction, urticaria, rhinitis after taking any NSAID. Diclogen gel and ointment should be used with caution when:

  • Pregnancy in the 1st and 2nd trimester;
  • Peptic ulcers of the gastrointestinal tract;
  • Hepatic porphyria;
  • Severe damage to the kidneys and liver;
  • Blood clotting disorders;
  • Bronchial asthma;
  • Chronic heart failure.

It is also necessary to prescribe the drug with caution in elderly patients.

Method of application and dosage

Diclogen according to the instructions in the form of a gel and ointment is used only for external use. The drug, for adults and children over 12 years old, is applied in a thin layer on the skin over the area of ​​inflammation 3-4 times a day and rubbed with light movements until completely absorbed, the bandage is not applied. The amount of Diclogen ointment and gel in a single dosage depends on the size of the painful focus and is 2-4 g (this is approximately equal to the size of a cherry), the daily dose should not exceed 8 grams. Children 6-12 years old are recommended to use the medication no more than 2 times a day, a single dose - no more than 2 g, daily - no more than 4 g. The duration of therapy usually does not exceed 7-14 days. After applying the gel or ointment Diclogen, wash your hands thoroughly, avoid getting the drug into the eyes and mucous membranes.

Side effects

Side effects of the drug use include local reactions in the form of: redness, itching, swelling, papules, peeling of the skin area treated with Diclogen. It is also possible the occurrence of eczema, photosensitivity, urticaria, generalized skin rash, angioedema, bronchospasm. With prolonged use, there may be Negative influence on the gastrointestinal tract, nervous system, and cardiovascular.

Terms and conditions of storage

The drug is stored away from light sources, in a dry place at a temperature not exceeding 30 ° C, the shelf life is not more than 36 months.

zdorovi.net

Diclogen gel - official instructions for use, analogues

catad_pgroup Local anti-inflammatory Analogues, articles Comments

INSTRUCTIONS

on the medical use of the drug

Registration number: P N013706/01-071008

Trade name of the drug: Diclogen®

International Nonproprietary Name (INN): Diclofenac

Dosage form: gel for external use

Composition: 1 g of gel contains: Active substance: Diclofenac diethylamine .............................................. ........11.6 mg equivalent to Diclofenac Sodium ......... 10 mg

Excipients:

Chlorocresol, liquid paraffin, carbomer 940, disodium edetate, propylene glycol, isopropanol, benzene alcohol, sodium sulfite, polysorbate 80, lavender oil, trolamine, purified water.

Description: Almost white translucent gel with a specific smell.

Pharmacological group: Non-steroidal anti-inflammatory drug (NSAID) ATX code M02AA15

Pharmacological action The active component of the drug diclofenac is a non-steroidal anti-inflammatory drug (NSAID), which has pronounced analgesic (pain-relieving) and anti-inflammatory properties. Indiscriminately inhibiting cyclooxygenase types 1 and 2, it disrupts the metabolism of arachidonic acid and the synthesis of prostaglandins, which are the main link in the development of inflammation.

Diclogen® is used to eliminate pain and reduce swelling associated with the inflammatory process. When applied topically, it causes the weakening or disappearance of pain in the joints at rest and during movement. Reduces morning stiffness and swelling of the joints, increases range of motion.

Pharmacokinetics When applied, systemic absorption is not more than 6%. Communication with proteins - 99.7%. Excreted by the kidneys.

Indications for use

  • Post-traumatic inflammation of soft tissues and joints, for example due to sprains, strains and bruises.
  • Rheumatic diseases of soft tissues (tenosynovitis, bursitis, damage to periarticular tissues);
  • Pain and swelling associated with diseases of the muscles and joints (rheumatoid arthritis, osteoarthritis, radiculitis, lumbago, sciatica, muscle pain of rheumatic and non-rheumatic origin).
Contraindications Hypersensitivity to diclofenac or other components of the drug, acetylsalicylic acid or other NSAIDs, anamnestic data on an attack of bronchial obstruction, rhinitis, urticaria after taking acetylsalicylic acid or other NSAIDs, pregnancy (III trimester), lactation period, childhood(up to 6 years), violation of the integrity of the skin.

With caution: hepatic porphyria (exacerbation), erosive and ulcerative lesions of the gastrointestinal tract, severe violations of the liver and kidneys, impaired blood clotting (including hemophilia, prolonged bleeding time, bleeding tendency), chronic heart failure, bronchial asthma, old age, pregnancy I and II trimester.

Use during pregnancy and during breastfeeding The drug should not be used in the third trimester of pregnancy. Experience with the use of the drug during lactation is not available. Use in the I and II trimesters is possible only after consulting a doctor.

Dosage and administration Externally. For adults and children over 12 years of age, the drug is applied to the skin 2 times a day and gently rubbed. The required amount of the drug depends on the size of the painful area. A single dose of the drug is up to 2 g (about 4 cm with a fully open neck of the tube). For children from 6 to 12 years of age, use no more than 2 times a day, a single dose of the drug up to 1 g (about 2 cm with a fully open neck of the tube). After applying the drug, hands must be washed.

The duration of treatment depends on the indications and the therapeutic effect. After 2 weeks of using the drug, you should consult your doctor.

Side effect Local reactions: eczema, photosensitivity, contact dermatitis (itching, redness, swelling of the treated area of ​​the skin, papules, vesicles, peeling). Systemic reactions: generalized skin rash, allergic reactions (urticaria, angioedema, bronchospastic reactions), photosensitivity.

Overdose The extremely low systemic absorption of the active components of the drug makes an overdose almost impossible. If accidentally swallowed large quantities gel (more than 20 g), systemic adverse reactions characteristic of NSAIDs may occur. It is necessary to wash the stomach, take activated charcoal.

Interaction with others medicines The drug may enhance the effect of drugs that cause photosensitivity. Clinically meaningful interaction with other drugs is not described.

Special instructions The gel should be applied only to intact skin, avoiding contact with open wounds. After application, an occlusive dressing should not be applied. Do not allow the drug to come into contact with the eyes and mucous membranes.

With prolonged use of large amounts of the drug, the occurrence of systemic side effects characteristic of NSAIDs cannot be excluded.

Release form Gel for external use 1%. 30 g or 50 g of gel in an aluminum or aluminum laminated tube.

1 tube with instructions for use in a cardboard box.

Storage conditions Store in a dry, dark place at a temperature not exceeding 25°C. Do not freeze.

Keep out of the reach of children.

Shelf life 3 years. Do not use after the expiration date.

Terms of dispensing from pharmacies Without a doctor's prescription

Producer "Agio Pharmaceuticals Ltd.",

A-38, Naijiot Ind. Estate, Kurla-Andheri Road, Safepool, Mumbai - 400072, India.

Claims of consumers should be sent to the address: 117105, Moscow, Nagorny proezd, 12 V

Diclogen gel is a drug for external use. It is applied to the joints and spine to eliminate pain, swelling, stiffness of movements. The drug is actively used in the treatment of inflammatory and degenerative-dystrophic pathologies. Rheumatologists, vertebrologists, orthopedists prescribe the drug to patients with arthrosis, arthritis, myalgia, neuralgia.

The instructions for use of the gel (ointment) recommend using Diclogen only after consulting a doctor. The active ingredient of the drug - diclofenac - can provoke allergic reactions. This scenario can be avoided by using Diclogen in the dosages recommended by the doctor.

Diclogen is a transparent gel with a slightly yellowish tint and a pleasant aroma of lavender essential oil. It is quickly absorbed by the skin, leaving no greasy marks on clothes and bedding.

The active ingredient diclofenac from the group of non-steroidal anti-inflammatory drugs penetrates directly into the pathological foci. Gel (cream, ointment) Diclogen has proven itself in the treatment of almost all diseases of the musculoskeletal system:

  • degenerative-dystrophic, occurring against the background of the gradual destruction of the cartilaginous surface of the bones;
  • inflammatory, often accompanied by joint pain, crunch, limited mobility.

According to the instructions for the Diclogen gel, its use allows you to reduce the doses of systemic drugs - analgesics, glucocorticosteroids. And this helps to reduce the pharmacological burden on internal organs: liver, kidneys, stomach.


Pharmacological group and action

Diclogen is included in the clinical and pharmacological group of non-steroidal anti-inflammatory drugs for external use. Its therapeutic effect is determined by diclofenac sodium, which blocks cyclooxygenase. It is under the action of this enzyme that prostaglandins, bradykinins, and leukotrienes are produced from arachidonic acid.

The less mediators are released into the bloodstream, the easier it is for patients to tolerate relapses of pathologies. Diclogen gel is characterized by a multifaceted positive effect on damaged joints, vertebrae, intervertebral discs:

  • relief of acute and chronic inflammatory processes in periarticular tissues;
  • weakening and elimination of painful sensations, "aches", burning sensations;
  • decrease in local body temperature;
  • elimination of even severe puffiness, morning swelling and stiffness of movements.

By stopping inflammation and swelling, diclofenac thereby stimulates the acceleration of blood circulation. Muscle tone decreases, the lumen of blood vessels increases, enough oxygen enters the articular structures. Cartilage, bone and soft tissues, ligaments and tendons are no longer deficient in nutrients. Regeneration is accelerated, which has a positive effect on the functioning of the joints.

Release form and composition


Diclogen 5% gel is produced in an Indian pharmaceutical factory. It is packaged in 30 g and 50 g aluminum tubes with screw caps. The Diclogen therapeutic line also includes capsules, 1% ointment, transdermal patch, eye drops and injection solution. Each gel tube is enclosed in a cardboard box along with instructions for use.

The active ingredient in the drug is one - sodium diclofenac, a derivative of phenylacetic acid. The auxiliary composition is represented by the following components:

  • paraffin;
  • isopropanol;
  • benzyl alcohol;
  • trolamine;
  • disodium edetate;
  • carbomer;
  • chlorocresol;
  • polysorbate;
  • propylene glycol;
  • sodium sulfite;
  • essential oil lavender.

Additional ingredients prolong (prolong) and enhance the analgesic and anti-inflammatory effects of diclofenac. Propylene glycol and lavender oil have antiseptic and antimicrobial properties and prevent tissue infection. This is especially true in the treatment of various kinds of injuries with Diclogen.

Instructions for use

It is advisable to use Diclogen in the treatment of lesions of soft tissues or joints, accompanied by severe pain. The gel contains a high concentration of diclofenac, which increases the likelihood of side effects. Therefore, doctors prescribe it to patients in cases where this risk is justified. And for the relief of mild inflammation and minor discomfort, it is better to use a 1% ointment of the same name.

When using the drug, you should adhere to the dosage regimen recommended by your doctor. Components can accumulate in the articular structures, and when a certain concentration is created, they penetrate into the blood. To prevent undesirable chemical interaction with other agents, maintaining a 15-minute interval between applications will allow.


Indications and contraindications

All dosage forms of Diclogen will help to cope with a decrease in the range of motion, pain, swelling. The gel is prescribed to patients both for the relief of acute pathologies, and for chronic exacerbations.

The drug is used to treat muscle diseases caused by inflammation or pinching of nerve endings. What else does Diclogen ointment help with:

  • different kinds arthritis - rheumatoid, reactive, metabolic, gouty, infectious;
  • deforming osteoarthritis, including coxarthrosis and gonarthrosis;
  • ankylosing spondylitis;
  • medial, lateral epicondylitis;
  • contractures, including post-traumatic ones;
  • lumbago, sciatica;
  • rheumatic pathologies of connective tissue structures;
  • humeroscapular periarthritis;
  • bursitis, synovitis, Becker's cyst;
  • cervical, thoracic, lumbosacral osteochondrosis;
  • tendinitis, tendovaginitis.

Indications for use are also muscle pain, provoked by excessive physical exertion. The use of the tool reduces the rehabilitation period after damage to the ligamentous tendon apparatus. Diclogen is prescribed for fractures, dislocations, including the usual ones.

The drug is contraindicated in children under 12 years of age, pregnant and lactating women. Its use is prohibited in case of individual intolerance to ingredients and other drugs from the NSAID group. Absolute contraindication - "aspirin triad". This is the name of the condition when taking acetylsalicylic acid leads to rhinitis, urticaria, bronchospasm.

Dosage and administration

The gel is applied only to intact skin in the area of ​​​​the joints up to 3 times a day. For better absorption, it must be pre-treated with antiseptic solutions. The external agent is evenly distributed and rubbed with light massaging movements.

Single doses vary. In case of pathologies of the hip joint, about 3 cm of a strip of gel is applied, the elbow - 1-2 cm.

The duration of the therapeutic course is 7-10 days. If necessary and in agreement with the doctor, treatment can be extended up to 2 weeks.


Side effects and special instructions

The instructions for use of Diclogen gel contain a warning about the inadmissibility of its application to large surfaces of the skin. In such cases, as well as when using the drug in high doses, the risk of side effects is high.

The most common symptoms of an allergic reaction: urticaria, skin rash, itching, swelling, burning. Less often, systemic side effects are diagnosed - headaches, nausea, vomiting, asthma attacks.

In case of violation of the functions of the liver, kidneys, organs of the cardiovascular system, single and daily doses are reduced. During treatment, the condition of such patients is monitored by a physician. If it worsens, the gel is canceled or replaced with 1% Diclogen ointment.

Pregnancy and lactation

The decision to use the gel during pregnancy and breastfeeding is made by the attending physician. The manufacturer did not provide data on the absence of a teratogenic effect of the drug. In the 3rd trimester, Diclogen is prohibited for use. For more early dates pregnancy, gel therapy is allowed, but only if safer means are ineffective.


Analogues

Structural analogues of Diclogen - ointments, gels Diclofenac, Voltaren, Ortofen, Diclovit, Diclak. Artrosilene, Indomethacin, Ibuprofen, Nimesulide have a similar therapeutic effect.


Gel for external use 5%

Composition

Diclofenac 50mg;

Auxiliary substances: chlorocresol, liquid paraffin, carbomer, trolamine, disodium edetate, propylene glycol, isopropanol, benzyl alcohol, benzyl alcohol, sodium sulfite, polysorbate 80, lavender oil, water

Pharmacodynamics

NSAIDs, a derivative of phenylacetic acid. It has a pronounced anti-inflammatory, analgesic and moderate antipyretic effect. The mechanism of action is associated with the inhibition of the activity of COX, the main enzyme of the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The analgesic effect is due to two mechanisms: peripheral (indirectly, through the suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system).

Inhibits the synthesis of proteoglycan in cartilage.

In rheumatic diseases, it reduces pain in the joints at rest and during movement, as well as morning stiffness and swelling of the joints, and increases the range of motion. Reduces post-traumatic and postoperative pain, as well as inflammatory edema.

Suppresses platelet aggregation. With prolonged use, it has a desensitizing effect.

When applied topically in ophthalmology, it reduces swelling and pain in inflammatory processes of non-infectious etiology.

Pharmacokinetics

After oral administration, it is absorbed from the gastrointestinal tract. Eating slows down the rate of absorption, while the degree of absorption does not change. About 50% of the active substance is metabolized during the "first pass" through the liver. When administered rectally, absorption is slower. The time to reach Cmax in plasma after oral administration is 2-4 hours, depending on the dosage form used, after rectal administration - 1 hour, intramuscular injection - 20 minutes. The concentration of the active substance in plasma is linearly dependent on the size of the applied dose.

Does not accumulate. Plasma protein binding is 99.7% (mainly albumin). Penetrates into the synovial fluid, Cmax is reached 2-4 hours later than in plasma.

It is largely metabolized to form several metabolites, of which two are pharmacologically active, but to a lesser extent than diclofenac.

The systemic clearance of the active substance is approximately 263 ml/min. T1 / 2 from plasma is 1-2 hours, from synovial fluid - 3-6 hours. Approximately 60% of the dose is excreted as metabolites by the kidneys, less than 1% is excreted in the urine unchanged, the rest is excreted as metabolites in the bile.

Side effects

From the digestive system: nausea, vomiting, anorexia, pain and discomfort in the epigastric region, flatulence, constipation, diarrhea; in some cases - erosive and ulcerative lesions, bleeding and perforation of the gastrointestinal tract; rarely - a violation of liver function. With rectal administration, in isolated cases, inflammation of the colon with bleeding, exacerbation of ulcerative colitis were noted.

From the side of the central nervous system and peripheral nervous system: dizziness, headache, agitation, insomnia, irritability, fatigue; rarely - paresthesia, visual disturbances (blurring, diplopia), tinnitus, sleep disorders, convulsions, irritability, tremor, mental disorders, depression.

From the hemopoietic system: rarely - anemia, leukopenia, thrombocytopenia, agranulocytosis.

From the urinary system: rarely - impaired renal function; edema may occur in predisposed patients.

Dermatological reactions: rarely - hair loss.

Allergic reactions: skin rash, itching; when used in the form of eye drops - itching, redness, photosensitivity.

Local reactions: at the site of the / m injection, burning is possible, in some cases - the formation of an infiltrate, abscess, necrosis of adipose tissue; with rectal administration, local irritation, the appearance of mucous secretions mixed with blood, painful defecation are possible; with external use in rare cases - itching, redness, rash, burning; when applied topically in ophthalmology, a transient burning sensation is possible

Selling Features

Released without a prescription

Special conditions

It is used with extreme caution in diseases of the liver, kidneys, gastrointestinal tract in history, dyspepsia, bronchial asthma, arterial hypertension, heart failure, immediately after major surgical interventions, as well as in elderly patients.

With a history of allergic reactions to NSAIDs and sulfites, diclofenac is used only in urgent cases. In the process of treatment, systematic monitoring of liver and kidney function, peripheral blood patterns is necessary.

It is necessary to avoid getting diclofenac in the eyes (with the exception of eye drops) or on mucous membranes. Patients using contact lenses, should apply eye drops no earlier than 5 minutes after removing the lenses.

During the period of treatment with dosage forms for systemic use, alcohol is not recommended.

Influence on the ability to drive vehicles and control mechanisms

During the period of treatment, a decrease in the rate of psychomotor reactions is possible. If visual clarity worsens after using eye drops, you should not drive a car or engage in other potentially hazardous activities.

Indications

Articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout) Pain in the spine, neuralgia, myalgia, arthralgia, pain syndrome and inflammation after operations and injuries, pain syndrome with gout, migraine, algomenorrhea, pain syndrome with adnexitis, proctitis, colic (biliary and renal), pain syndrome with infectious and inflammatory diseases of the ENT -organs.

For local use: inhibition of miosis during cataract surgery, prevention of cystoid macular edema associated with removal and implantation of the lens, inflammatory processes of the eye of a non-infectious nature, post-traumatic inflammatory process with penetrating and non-penetrating wounds of the eyeball.

Contraindications

Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, the "aspirin triad", hematopoietic disorders of unknown etiology, hypersensitivity to diclofenac and the components of the dosage form used, or other NSAIDs.

drug interaction

With the simultaneous use of antihypertensive drugs with diclofenac, their action may be weakened.

There are isolated reports of the occurrence of seizures in patients taking NSAIDs and antibacterial drugs of the quinolone series at the same time.

With simultaneous use with GCS, the risk of side effects from the digestive system increases.

With the simultaneous use of diuretics, a decrease in the diuretic effect is possible. With simultaneous use with potassium-sparing diuretics, an increase in the concentration of potassium in the blood is possible.

When used simultaneously with other NSAIDs, the risk of side effects may increase.

There have been reports of hypoglycemia or hyperglycemia in patients with diabetes who used diclofenac simultaneously with hypoglycemic drugs.

With simultaneous use with acetylsalicylic acid, a decrease in the concentration of diclofenac in the blood plasma is possible.

Registration number: P N013706/01-071008

Trade name of the drug: Diclogen ®

International nonproprietary name (INN): Diclofenac

Dosage form: gel for external use

Composition: 1 g of gel contains:
Active substance:
Diclofenac diethylamine..............................................11, 6 mg
equivalent to the content of Diclofenac sodium......... 10 mg
Excipients:
Chlorocresol, liquid paraffin, carbomer 940, disodium edetate, propylene glycol, isopropanol, benzene alcohol, sodium sulfite, polysorbate 80, lavender oil, trolamine, purified water.

Description: Almost white translucent gel with a specific odor.

Pharmacological group: Non-steroidal anti-inflammatory drug (NSAID)
ATX Code M02AA15

pharmachologic effect
The active component of the drug diclofenac is a non-steroidal anti-inflammatory drug (NSAID), which has pronounced analgesic (pain reliever) and anti-inflammatory properties. Indiscriminately inhibiting cyclooxygenase types 1 and 2, it disrupts the metabolism of arachidonic acid and the synthesis of prostaglandins, which are the main link in the development of inflammation.
Diclogen ® is used to eliminate pain and reduce swelling associated with the inflammatory process. When applied topically, it causes the weakening or disappearance of pain in the joints at rest and during movement. Reduces morning stiffness and swelling of the joints, increases range of motion.

Pharmacokinetics
When applied, systemic absorption is not more than 6%. Communication with proteins - 99.7%. Excreted by the kidneys.

Indications for use

  • Post-traumatic inflammation of soft tissues and joints, for example due to sprains, strains and bruises.
  • Rheumatic diseases of soft tissues (tenosynovitis, bursitis, damage to periarticular tissues);
  • Pain and swelling associated with diseases of the muscles and joints (rheumatoid arthritis, osteoarthritis, radiculitis, lumbago, sciatica, muscle pain of rheumatic and non-rheumatic origin).
Contraindications
Hypersensitivity to diclofenac or other components of the drug, acetylsalicylic acid or other NSAIDs, anamnestic data on an attack of bronchial obstruction, rhinitis, urticaria after taking acetylsalicylic acid or another NSAID, pregnancy (III trimester), lactation, children's age (up to 6 years), violation integrity of the skin.
Carefully : hepatic porphyria (exacerbation), erosive and ulcerative lesions of the gastrointestinal tract, severe violations of the liver and kidneys, impaired blood clotting (including hemophilia, prolongation of bleeding time, tendency to bleed), chronic heart failure, bronchial asthma, old age, pregnancy I and II trimester.

Use during pregnancy and during breastfeeding
The drug should not be used in the third trimester of pregnancy. Experience with the use of the drug during lactation is not available. Use in the I and II trimesters is possible only after consulting a doctor.

Dosage and administration
Outwardly. For adults and children over 12 years of age, the drug is applied to the skin 2 times a day and gently rubbed. The required amount of the drug depends on the size of the painful area. A single dose of the drug is up to 2 g (about 4 cm with a fully open neck of the tube). For children from 6 to 12 years of age, use no more than 2 times a day, a single dose of the drug up to 1 g (about 2 cm with a fully open neck of the tube).
After applying the drug, hands must be washed.
The duration of treatment depends on the indications and the therapeutic effect. After 2 weeks of using the drug, you should consult your doctor.

Side effect
Local reactions: eczema, photosensitivity, contact dermatitis (itching, redness, swelling of the treated area of ​​the skin, papules, vesicles, peeling).
Systemic reactions: generalized skin rash, allergic reactions (urticaria, angioedema, bronchospastic reactions), photosensitivity.

Overdose
The extremely low systemic absorption of the active components of the drug makes an overdose almost impossible. In case of accidental ingestion of large amounts of gel (more than 20 g), systemic adverse reactions characteristic of NSAIDs may occur. It is necessary to wash the stomach, take activated charcoal.

Interaction with other drugs
The drug may enhance the effect of drugs that cause photosensitivity. Clinically significant interactions with other drugs have not been described.

special instructions
The gel should only be applied to intact skin, avoiding contact with open wounds. After application, an occlusive dressing should not be applied. Do not allow the drug to come into contact with the eyes and mucous membranes.
With prolonged use of large amounts of the drug, the occurrence of systemic side effects characteristic of NSAIDs cannot be excluded.

Release form
Gel for external use 1%.
30 g or 50 g of gel in an aluminum or aluminum laminated tube.
1 tube with instructions for use in a cardboard box.

Storage conditions
Store in a dry, dark place at a temperature not exceeding 25°C.
Do not freeze.
Keep out of the reach of children.

Shelf life
3 years. Do not use after the expiration date.

Terms of dispensing from pharmacies
Without a doctor's prescription

Manufacturer
Agio Pharmaceuticals Ltd.,
A-38, Naijiot Ind. Estate, Kurla-Andheri Road, Safepool, Mumbai - 400072, India.

Consumer complaints should be directed to:
117105, Moscow, Nagorny proezd, 12 V

Diclogen belongs to the group of non-steroidal anti-inflammatory drugs..

Pharmacological action of Diclogen

Diclogen is an NSAID, a derivative of phenylacetic acid, due to which it has an analgesic and anti-inflammatory effect.


The drug reduces the amount of Pg, taking into account the area in the focus of inflammation, and disrupts the metabolism of arachinoid acid. Thanks to the water-ethanol base, Diclogen is also able to provide a local anesthetic effect.

Release form

The most common dosage forms are:

  • ointment Diclogen;
  • cream;
  • gel.

All these drugs are intended for external use.

Indications for use Diclogen

According to the instructions for Diclogen, the drug is indicated for use in:

  • diseases of the musculoskeletal system (including juvenile, chronic, rheumatoid, gouty, psoriatic arthritis, rheumatic lesions of soft tissues);
  • traumatically caused inflammation of the joints, ligaments, muscles and tendons;
  • pain syndrome.

Contraindications

Among the contraindications to Diclogen can be called hypersensitivity to any component of the drug, violation of the integrity of the skin.

With caution, the drug is prescribed to pregnant and lactating women, the elderly, as well as patients suffering from hepatic porphyria, erosive and ulcerative lesions of the gastrointestinal tract, blood clotting disorders, severe impairment of kidney and liver function, "aspirin asthma".

Diclogen's instruction: methods of application


Cream and ointment Diclogen is applied in a thin layer to the skin over the focus of inflammation, then lightly rubbed into the skin. The procedure should be done 2-3 times a day, but the maximum daily dose should not exceed 8 g. On average, the course of treatment lasts 7-14 days.

Diclogen gel should be applied 3-4 times a day. The amount of gel should be approximately 2-4 grams (this is approximately the size of a cherry and walnut), it all depends on the area of ​​inflammation. The gel should be applied directly to the affected areas, and then rubbed gently. To enhance the effect, it can be combined with other drugs.

After applying the cream, ointment or gel, wash your hands thoroughly.

Side effects of Diclogen

Reception of Diclogen is sometimes accompanied by side effects , which can manifest themselves on the part of the skin (dermatitis, puffiness, eczema, etc.). Also, allergic reactions can be observed in the form of urticaria, burning and itching of the skin, antineurotic edema, erythematous skin rash, and various anaphylactic reactions.

With a fairly long-term use of the drug, the digestive system, sensory organs, as well as the respiratory and nervous system. There may also be problems with the cardiovascular system.

Storage conditions

Store in a dark place for no more than 3 years.

Sincerely,


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